Mediaseed - Microbubbles Developed to Administer Medications That Fight Cancer and Reduce Side Effects

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Microbubbles Developed to Administer Medications That Fight Cancer and Reduce Side Effects

Source: Philips

New Technology May Offer Patients Less Invasive Treatment Options

September 2008 (Medialink) - More and more cancer patients are looking for treatment options that allow them to maintain their quality of life during difficult treatment regimens.

Philips Research is developing a new ultrasound-based drug delivery technology designed to increase the effectiveness and reduce the side effects of chemotherapy treatment for certain types of cancer. The system proposes the use of drug-loaded microbubbles, no larger than red blood cells, that can be injected into the patient's bloodstream, tracked via ultrasound imaging and then ruptured by a focused ultrasound pulse to release their drug payload when they reach the desired spot. Because the drugs would only be released at the site of the diseased tissue, the patient's total body exposure to them could be limited.

Researchers say pre-clinical studies have shown the treatment to have the potential to reduce negative side effects in chemotherapy procedures. By avoiding these side effects associated with traditional therapies, these interventions could increase patient comfort and result in faster recovery.

Contact:
Julia Heath, (212) 812-7097
JHeath@medialink.com

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Ultrasound imaging technology is already used to image what is going on inside the patient. Scientists at Philips Research are developing a localized drug delivery system based on ultrasound and microbubbles that are partially filled with cancer drugs.

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The microbubbles are tiny gas-filled spheres of biodegradable material no bigger than red blood cells. These are to be injected into the patient’s bloodstream and carried to the site of a tumor. The arrival of the microbubbles at the tumor can be monitored with ultrasound imaging.

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Upon arrival of the microbubbles in the tumor, they will then be ruptured with a focused ultrasound pulse to release the drugs.

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As the drugs are only released at the site of the tumor, the patient’s total body exposure to them could be limited, which for certain types of cancer could help to reduce the unpleasant side effects of chemotherapy.

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Ultrasound Mediated Drug Delivery Press Release

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Ultrasound Mediated Drug Delivery Backgrounder

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